Distribution of cytochrome P450*4 (CYP2A6*4) allele gene among Javanese Indonesian T2DM patients

Smoking had been increasing the risk factor of type 2 diabetes mellitus (T2DM), both active and passive smokers, which is caused by nicotine contained in cigarettes. Nicotine has metabolized cytochrome p450 2a6 (CYP2A6) enzyme coded CYP2A6 gene. This gene was a high polymorphism that CYP2A6*4 allele inactive. Thus, our objective to describe among Javanese smokers with T2DM. From this cross-sectional study, we identified 46 adults T2DM, were consist 23 smokers. The identification done using polymerase chain reaction (PCR) methods. frequency analyzed distribution participants. study supports hypothesis smoking, including cigarette smoke, an environmentally modifiable for developing Based on result, participants 42.39%. A CYP2A4 indicating also other